Achufusi TGO, Patel RK. Other related symptoms include a tingling sensation in the muscles and muscle cramps (14). However, the extracts in milk thistle could act like estrogen. Can Apoaequorin Really Improve Your Memory? The common name, milk thistle, is derived from the "milky white" veins on the leaves, which, when broken open, yield a milky sap. Milk thistle is an annual or biennial herb native to the Mediterranean region, which has been used for centuries as a food and as a medicinal herb for treatment of liver conditions. Fried MW, Navarro VJ, Afdhal N, et al. Milk thistle side effects (more detail) 2005;100(11):2583-91. doi:10.1111/j.1572-0241.2005.00262.x. Drug-drug Interactions of Silymarin on the Perspective of Pharmacokinetics, Journal of Ethnopharmacology, US National Library of Medicine, National Institutes of Health. Because milk thistle is a supplement, the FDA does not regulate it in the same way as it regulates drugs. Silymarin, an active component of milk thistle, may improve liver function and reduce symptoms of cirrhosis, or scarring of the liver. List Milk Thistle Capsule side effects by likelihood and severity. Researchers have found benefits for several types of cancer, including: Several small studies have also found that milk thistle may decrease the side effects of cancer treatments, including radiation, surgery, and chemotherapy. Store milk thistle supplements in a cool, dry place. Dosage: How Much Milk Thistle Should I Take? Keep supplements in areas out of the reach of pets and children. In some studies, silibinin, an active component of milk thistle, has been shown to have estrogen-like effects. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. If you have any questions about storage, ask your pharmacist. It's typically recommended to avoid taking multiple supplements for the same cause at the same time. Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. 3. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. The following two tabs change content below. Others may find them inefficient, while some people swear by them. Yes, you can take milk thistle long term. The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. One of milk thistle's traditional uses is easing indigestion. What Are the Side Effects of Milk Thistle? Duplication is encouraged. Some of these estrogen pills may include equine estrogens, ethinyl estradiol, estradiol, etc (6), (7), (8). Consult with your healthcare provider if you experience these and other side effects to find out the best way to proceed. Effects of Silybum marianum (L.) Gaertn. Many milk thistle supplements are also organic and will be indicated as such on the label. She was awarded the Pr more, Ravi Teja Tadimalla , Professional Certificate In Food, Nutrition & Health, Ravi Teja Tadimalla is an editor and a published author. In a 2016 study, researchers fed rats a high-cholesterol diet. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. It could help the body fight off infection as well as reduce chronic inflammation produced by the immune system. 2011;17(18):2288-2301. doi:10.3748/wjg.v17.i18.2288. One study questioned the benefits of milk thistle for liver diseases. It also seems to have antioxidant and anti-inflammatory effects. Certain people should take precautions when using milk thistle, and others may need to avoid it altogether. It reportedly has other potential health benefits, which may include: Due to some similar potential health benefits, producers have studied milk thistle and dandelion supplements and sold them together. It also looks at how to use milk thistle and whether there are any risks to consider. 2023 Dotdash Media, Inc. All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Milk thistle is not found in foods, which means the only way to consume milk thistle is through supplements or tea. Although some studies have shown positive results on milk thistle for people with chronic hepatitis C virus (HCV) infection, the overall research does not show a benefit. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial, Silymarin in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials, Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials, The Natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis, Silybin and the liver: from basic research to clinical practice, Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review, The therapeutic potential of milk thistle in diabetes, Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial, Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study, Resveratrol for the management of diabetes and its downstream pathologies, Milk thistle: effects on liver disease and cirrhosis and clinical adverse effects: summary. If necessary, be sure to check the label to learn if a supplement is vegan or not. You may report side effects to FDA at 1-800-FDA-1088. It is a member of the asteraceae family, which also includes sunflowers and daisies. Milk Thistle: Effects on Liver Disease and Cirrhosis and Clinical Adverse Effects: Summary, AHRQ Evidence Report Summeries, National Center for Biotechnology Information, U.S. National Library of Medicine. Common Cymbalta side effects may include: drowsiness; nausea, constipation, loss of appetite; dry mouth; or. Email this report to a friend, doctor, or patient. Small Business Research Grant Program (SBIR), About Research Training and Career Development, Training Grant Application, Review, and Award Process, Integrative Medicine Research Lecture Series, Division of Extramural Research Sponsored by NCCIH, Division of Intramural Research Conducted at NCCIH, Know the Science: How Medications and Supplements Can Interact, Know the Science: 9 Questions To Help You Make Sense of Health Research, How To Find Information About Complementary Health Approaches on PubMed, Dietary Supplements: What You Need To Know. Milk thistle may help to stop the spread of certain types of cancer. We explore the potential health benefits of milk thistle below. There are no guidelines regarding a standard dose of milk thistle. Occasionally, people report various digestive side effects. Natural Medicines website. Evidence and risks, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, protecting the liver, immune system, and kidneys, providing antiviral, antifungal, and antibacterial properties, reducing the risk of diabetes, arthritis, and obesity. Gillessen A, Schmidt HH. Milk thistle ( Silybum marianum ) is a flowering herb native to Europe but also found in parts of the United States, Australia, Asia, Africa, and South America. Phytomedicine. How this happens is yet to be studied. The FDA has not approved milk thistle to treat any health conditions. For this reason, it is important to buy milk thistle from reputable retailers. Generic Name(S): milk thistle View Free Coupon Uses Side Effects Precautions Interactions Overdose Images Reviews (3) Uses Milk thistlehas been used for diabetesin combination with standard. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. Milk thistle may interfere with the following medications, because both milk thistle and these medications are broken down by the same liver enzymes: Reviewed By: Steven D. Ehrlich, N.M.D., private practice specializing in complementary and alternative medicine, Phoenix, AZ. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product. Some, but not all, milk thistle supplements are vegan. Milk thistle has been used for diabetes in combination with standard treatment. Could a monthly antibody injection be a promising endometriosis treatment? Some of these drugs may include Mevacor, Lescol, Zocor, Pravachol, and Baycol. You might also get the herb at your nearest supermarket/pharmacy. (2021). Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. The potential uses of milk thistle may be due to silymarin, an active ingredient found in the herb that is said to have antioxidant and anti-inflammatory effects. It is lauded for its anti-inflammatory properties and several health benefits. Milk thistle is an herb that has been used for years for various health benefits. Milk thistle. Some research also states that overall, milk thistle may not pose a great risk for drug interactions in humans (13). Rambaldi A, Jacobs BP, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases. It is also unknown whether milk thistle is safe for children. In: StatPearls. You may report side effects to FDA at 1-800-FDA-1088. Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Check out our. Do not double the dose to catch up. This is not a complete list of side effects and others may occur. Does milk thistle cause any side effects? J Diabetes Res. Common side effects of milk thistle reported in studies include: Typically, side effects will subside once you stop using milk thistle. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. The following list is not exhaustive. This is not a complete list of side effects and others may occur. Milk thistle might also decrease hormone levels in the body (5). What. Usually avoid combinations; use it only under special circumstances. You can learn more about how we ensure our content is accurate and current by reading our. A small number of studies have suggested that milk thistle extract might be beneficial for diabetes, but the conclusions about its effectiveness are not definite. Milk thistle can also cause an allergic reaction in some people. When possible, choose a supplement that has been tested by a trusted third party, such as USP, ConsumerLabs, or NSF. Talk to your pharmacist for more details. Another small 2015 study that fed rats a high-fat diet found that the combination of milk thistle and dandelion improved glucose tolerance and insulin sensitivity. A 2013 study found that milk thistle helped to prevent bone loss. Before using this product, tell your doctor or pharmacist of all the products you use. Does Milk Thistle Capsule interact with other drugs you are taking? However, there is a lack of . We know little about whether milk thistle is effective in people, as only a few well-designed clinical studies have been conducted. 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