Scientists discover how to prevent death of nerve cells in most common forms of MND and dementia Researchers from the University of Sheffields Institute of Follow South Yorkshire Live or My Sheffield on Facebook and Twitter for the latest Sheffield news and follow Yorkshire Live on Instagram for beautiful images and stories. Jason Bennett said he was heartbroken at the loss of daughter Lacey, 11, and son John Paul, 13, as he laid flowers at Chandos Crescent, Killamarsh. Both are due to appear before Sheffield Magistrates' Court on Saturday. "Their dad was on holiday in Devon. South Yorkshire Police said: "Emergency services were called at around 3.45pm yesterday (Sunday, 25 April) following reports of concern for a woman in High Hazels Park, Sheffield. The crash happened on December 9 at around 9pm and involved a black Toyota MR2 which was travelling along Hanover Way towards Moore Street roundabout. WebLive Sheffield news, including the latest headlines on travel, crime, local politics, M1 updates, events and much more on South Yorkshire's largest settlement. Instead of using conventional drugs, which are inefficient in disrupting the stickiness of the SRSF1 protein, or invasive therapies to edit or modulate the activity of defective genes, the new study found that a small peptide incorporating a cell-penetrating module can stick to SRSF1 and effectively block the transportation of the rogue repeat RNA. Or by navigating to the user icon in the top right. Many of those arriving to pay their respects had young children themselves. "I just want to kiss them and hold them. This means the peptide is effectively blocking the progression of the neurodegenerative condition and also helping to restore the function to the affected nerve cells. 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"So far we've had a gentle flow of people who are coming in," said the rector. "And it is a day that we'll all remember because this doesn't happen in Killamarsh. Following the vigil he told the BBC: "Many of them wanted to be able to come and show their feelings for one another, for the community and to be there to support one another. 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Welcome back Edit Account-Sign Out. Terri was a beautiful and wonderful mother. Office: 01-142-229-859, Copyright 2023 by the American Association for the Advancement of Science (AAAS), /Life sciences/Biochemistry/Biomolecules/, /Life sciences/Biochemistry/Biomolecules/Proteins/, /Life sciences/Biochemistry/Biomolecules/Proteins/Membrane proteins/, /Life sciences/Neuroscience/Cellular neuroscience/Neurons/, /Social sciences/Psychological science/Clinical psychology/Cognitive disorders/, Researchers from the University of Sheffields Institute of Translational Neuroscience have discovered how to prevent the death of nerve cells and protect nerves from neurodegeneration in the most common forms of MND and frontotemporal dementia, The researchers used a peptide, a small assembly of amino acids or protein bricks, with a cell-penetrating module to stop mutant repeated RNA molecules being transported from the cell's nucleus to the cytoplasm where they are used to produce toxic repeat proteins which lead to the death of nerve cells, Findings of the study suggest the peptide could be given orally in a non-invasive manner - for example through a nasal spray which could be developed to enter the brain, The groundbreaking concept of using peptides to block the nucleus-to-cytoplasm transport of the damaging repeat expanded RNA could transform how some neurodegenerative conditions, which currently have no cure, are treated. There is no cure for FTD, and no treatments available to slow or stop the progression of the disease. It said Mohammed's death was not being treated as suspicious and his family was being supported by officers. "We have a large scene in place in the city centre while we carry out enquiries.. Read about our approach to external linking. Media contact: For more information please contact: Amy Huxtable, Media and PR Officer, University of Sheffield, 07568116781, a.l.huxtable@sheffield.ac.uk Journal Science Translational Medicine Mr Bennett added: "He's going to need a lot of help and our strength for him. Ukrainian refugee family A woman has been found dead at a flat in Sheffield after officers forced entry to the property. Sheffield, Yorkshire. Read about our approach to external linking. FTD occurs when nerve cells in the frontal and temporal lobes of the brain are lost, causing the lobes to shrink. The housing group Mears was looking after the hotel until a few months ago, but safety concerns saw it withdraw to another nearby hotel. Send your story ideas to eastmidsnews@bbc.co.uk. The peptide is composed of a short chain of amino acids or bricks found within our cells and tissues in the body. The city is also home to Sheffield Arena, a popular venue, and the large shopping centre Meadowhall. WebLive-event. "Everybody, if you want to talk to them, they have no time because they are so bad, in a bad condition.". South Yorkshire Police have sealed off Sarah Brierley died from serious head injuries, police say, Police forced entry into the flat on Monday morning. Once in the UK however, the Home Office is struggling to find accommodation for refugees - many of whom are large families. She said officers were particularly keen to speak to anyone who was in Chandos Crescent between 21:30 BST on Saturday and 07:30 BST on Sunday, and had any information that could help with their investigation. Enquiries are ongoing and he remains in police custody at this time. Mary E. Fisher Hallam. The family of two children, who were found dead along with their mother and another child at a house in Derbyshire, have paid tribute to them. Posted. "They are so upset, they are so unhappy," he said. Professor Guillaume Hautbergue, Professor of Translational RNA Biology at the University of Sheffield, who led the study said: When we tested our innovative approach by adding the peptide to the food eaten by fruit flies not only did the peptides block the damaging mutations which cause MND and FTD from being transported to the cell's nucleus, we actually saw an improvement in their neurofunction. Or by navigating to the user icon in the top right. The BBC is not responsible for the content of external sites. A woman has died after being found "on fire" in a Sheffield park. It also left three other people needing We're proud to work with local and global organisations to further enhance our translational research. The BBC is not responsible for the content of external sites. The BBC is not responsible for the content of external sites. MND is a debilitating condition that destroys the cells that control movement, leaving sufferers unable to move, walk, talk and eventually breathe. The man said the eight to 10 Afghan families staying at the hotel were being moved to another hotel on Thursday afternoon. In a message posted on Facebook earlier, he said "life will never be the same". 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A five-year-old Afghan refugee who fell to his death from a Sheffield hotel window has been identified by police. I have three children and it was a very anxious time yesterday, not knowing what was happening. This means that we may include adverts from us and third parties based on our knowledge of you. A woman has been found dead at a flat in Sheffield after officers forced entry to the property. There had been concerns raised about the safety of the windows. A woman has been found dead at a flat in Sheffield after officers forced entry to the property. The Sheffield team previously discovered the abnormal transportation of the rogue RNAs copied from the C9ORF72 gene - known to be the most frequent cause of MND and FTD - is caused by excessive stickiness of a cell transporter named SRSF1. As always you can unsubscribe at any time. This is a promising alternative to conventional small molecule drugs which are often limited by poor penetration of the blood-brain barrier.. In a statement, South Yorkshire Police said: "Shortly after 3am this morning (6 November), a man was discovered unconscious in Pond Street, Sheffield. Send your story ideas to yorkslincs.news@bbc.co.uk. "Sadly, the woman was pronounced dead at the scene. The Universitys four flagship institutes bring together our key strengths to tackle global issues, turning interdisciplinary and translational research into real-world solutions. Read about our approach to external linking. At the scene: Caroline Lowbridge, BBC News, 1894 shipwreck confirms tale of treacherous lifeboat. South Yorkshire Police have confirmed that emergency services were called to High Most patients with the disease are only expected to live two to five years after diagnosis. Promising MND drug helps slow disease progression and benefits patients physica. JB. A large cordon is in place and is being guarded by officers. Copy Citation. 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