Last time I took my Collies to a pet store here in parasite-infested Florida, I asked one of the clerks what they sold the most of as far as flea and tick preventives. Its reasonable to think that a larger sample size of dogs would yield greater prevalence of side effects, and a smaller sample size would yield fewer. Anecdotally anyway, it is reported to have gentler ingredients and the least tendency to cause skin irritations. Hi Debbie! You probably already know Frontline Gold can be toxic to cats, since it has a caution on the label, but this is only really a concern if you have a cat who cuddles with or grooms your dogs. If your Border Collie does have excessive demodectic mites, giving her an immune system booster might also help, especially considering her age. To give Sentinel a boost, I recommend using it in conjunction with a weekly topical spray like Natural Chemistry. Do not administer to dogs that are sick, debilitated, underweight, have a history of weight loss, or to those previously found to be hypersensitive to the drug. Mary. Simparica Trio should be given orally once a month at the recommended minimum doses: 0.54 milligrams of sarolaner, 0.011 mlilligrams of moxidectin, and 2.27 milligrams of pyrantel per pound of body weight. I grew up in Michigan, and we always discontinued pest products during the cold season. I had never heard of Dimmitrol before, but I did some research after reading your comment. Buy Simparica Trio for Small dogs 5.1-10Kg. Is Simparica trio safe for dogs with the MDR1 gene? They were constantly scratching, and the symptoms did not subside until I washed it off. Thank you so much for all your hard work and care given to writing this very informative and extremely important study greatly appreciate it , I would like to thank you for your very thorough but get to the point info of all these parasitic treatments We have a rough Collie I could not find any info on safe treatments without wading through a river of muck. Please keep me updated if you think of it! Background: The efficacy and safety of a novel isoxazoline compound, sarolaner (Simparica , Zoetis) and spinosad (Comfortis , Elanco) as a positive control were evaluated for the treatment and control of natural flea infestations on dogs in two randomised, blinded, multi-centric clinical trials conducted in 11 veterinary clinics in northeastern and southeastern states of Australia. Hi Emily, Another thing to research and to ask your personal vet about might be potential drug/drug interactions between the Trazadone and Effifax, or whichever parasite preventives you choose to use in the future. Either Sentinel or Interceptor are generally considered safe for Collies and can be used to treat demodectic mange. Regardless of the heartworm product you choose, as the Institute of Pharmacology and Toxicology says, treatment of MDR1 mutant dogs with macrocyclic lactones in general requires particular caution. It really boils down to weighing the benefits of medications against the risks from internal parasites. Just checking in to see how you and your pup are doing and if you ended up using Seresto collars or not. Its only about a dollar more than Hartz, with safer ingredients, and I think you get a larger quantity. Two dogs were positive for D. immitis antigen but not MF on days 210 and 236. Because I am only one person, the medication is relatively new, and it has active ingredients that are the same as more well-known medications that have been known to cause issues for many dogs, I didnt feel that I could give it an entirely glowing recommendation. How to use Simparica Trio. Thank you for all the research, it was all so helpful. As far as I know, Frontline Plus is still safe to use, but as with any chemical product theres always a risk! Moxidectin, the heartworm-fighting portion of Advantage, is considered safe if the proper dosage is given monthly, but it did not test as well as either selamectin or milbemycin oxime in clinical trials, though it ranks above Ivermectin. Your article has been very helpful in my quest to help my forest loving dog stay safe from tics. (If you order online, keep in mind that the company will first have to contact your veterinarian for a prescription to be issued, which may slightly delay the shipping time.). Simparica Trio is proven to kill 5 species of ticks. Thanks for your efforts to help! Kills 5 types of ticks. Most veterinarians in my area are still prescribing Bravecto, simply because they arent yet comfortable enough with Credelio. Sarolaner is also a component of the combination drug Simparica Trio, which contains sarolaner, moxidectin, and pyrantel. I myself have successfully used both on my 2 Collies and my Aussie mix with no ill effects. Thank you very much! My thought was to put on a collar in the morning and take it off at night when she will safely be back in the house. Simparica Trio can be used from 8 weeks of age in animals over 1.25kg. . I cant speak from personal experience on this, but the Seresto effectiveness/safety question has come up in an international Rough Collies group Im part of on Facebook. I will not give anything oral to my dog, since our first collie was probably killed by heartworm preventative. Simparica Trio is generally well tolerated at the recommended dose; adverse reactions (t ransient ataxia and/or muscle fasciculation in dogs with a deficient multidrug -resistance-protein 1 (MDR1 -/-)) are only seen at overdoses. Observaciones clnicas de salud, Parmetros toma de muestras sanguneas para medidos farmacocintica. Thank you for this. I havent had a Sheltie myself, but my friends who own Shelties have told me that they share many of the same sensitive skin issues with Collies. Unfortunately, the fleas are fighting back. However, its technically safe so long as it isnt applied past the shoulder blades where your Collie could reach it. He said Elanco is very conscientious about safety (particularly since Interceptor is used by so many people who have MDR1-prone dogs), and even with his advice I still stood there reading the label and agonizing over my decision before I decided to give it a try! Dogs with normal MDR1 genes can usually tolerate oral dosages as high as 2,500 mcg/kg of body weight before signs of toxicity are seen, while dogs with two copies of the defective MDR1 gene can tolerate only up to 100 mcg/kg of oral ivermectin. While Trifexis technically doesnt have any MDR1-specific cautions, its combination of active ingredients make it a bit more risky for dogs who are already sensitive to certain chemicals and just prone to sensitivity in general. Thank you for the reminder! . I am currently fostering 3 rescued puppy mill border collie females with sarcoptic mange. I had success giving Credelio (active ingredient lotilaner instead of Simparicas sarolaner), but in all honesty I administered that based on my vets recommendation BEFORE I realized the FDA warning also applied to Credelio. Hello! Simparica comes as flavored, chewable tablets and is available in a variety of sizes: 5, 10, 20, 40, 80, and 120 mg. 6. Thank you! An added benefit is it has been around long enough that cheaper generic products are available, some of which Ive tried and found to be as effective as Frontline. I was leaning towards, but have not tried, the combination of Interceptor tablets (heartworm) + Credilio (flea and tick) tablets. Best of luck with your girl. Thank you so much for writing this article!!! Doses used for heartworm prevention are safe to use in these breeds of dogs. Simparica Trio chewable tablets for dogs 1.25-2.5 kg Simparica Trio chewable tablets for dogs >2.5-5 kg . (My dogs dont groom each other or really play that way now that theyre older and settled, so I feel comfortable using topicals now.) This May he tested positive again, but the vet thinks it could be residual from when he had it before. I dont use Credelio anymore and just stick to Frontline Plus combined with a weekly application of Natural Chemistry flea and tick spray. Just as another concern, I had two cats die from Advantage Multi. The MDR1 mutation is believed to occur in approximately 50% of Australian Shepherds. I just dont know what to do about heartworm treatment and wonder if Interceptor instead of Interceptor Plus would be a better option or more of the same. Eur. I would appreciate your comments on Advocate. Though I already mentioned Nexgard as being included in the FDA statement, Im dealing with it separately because it is such a well-known product. Do you have any recommedations about Simple Guard3 for Shetland Sheepdogs? Until progress is achieved in ongoing studies, adjustments are made to the medications themselves, and the FDA warning is lifted, Ill have to leave Bravecto in the caution category. Enjoy your girl! It also helps to know your dogs MDR1 statuses, which can be checked through places like Paw Print Genetics. I'm planning to go on a camping trip mid-September and my vet prescribed a simparica trio tablet to make sure he's safe from fleas and ticks. Nexgard Spectra. It is safe for use with anthelmintics like heartworm meds and has no known negative drug-drug interactions. ? I have a 3 year old and an 11 week old Australian Shepherd. Fleas can lay up to 1300 eggs within 50 days, 4 but Simparica Trio kills them before they can even lay eggs. Very recently, significantly increased brain penetration of fluralaner was demonstrated in an mdr1 mutant mouse model, indicating that MDR1-mediated drug efflux normally prevents fluralaner entry into the brain [ 21 ]. Later, the vet had the experience of this happening to other cats and one of his own. Hope this helps! We do, however, have lots of deer ticks (also known as black legged ticks). But Ive given it a caution designation as it should not be given in combination with heartworm meds and is not safe for dogs who are at risk for seizures. As with any topical product, monitor your pet for signs of skin irritation, and give them a bath within 24 hours to wash it off if signs of irritation are seen. Your such a good writer,thank you so much for posting this very informative article.In this way it will greatly help keep our pets safe. I was unaware of MDR1 Mutation drug reactions at the time. GSD is an abbreviation for German Shepherd Dog , Thankyou so much for your articleso much great infoI have a 7 month mini Aussieon Symparticabut not feeling good about itshe hasnt been tested for MRD1 but I know I have to change it upthankyou again , Youre very welcome, and good luck with your pup! Whats the best safest flea tick treatment for a collie puppy? Simparica TRIO requires a prescription from your veterinarian. That is my concern. Simparica Trio Chewable Tablets for Dogs. Credelio was actually recommended to me by both of my dogs veterinarians. (Some of the links lead to peer-reviewed scientific articles, so have fun with those if you want the bare, dusty facts.). This product contains moxidectin (a macrocyclic lactone), therefore special care should be taken with Collies, Old English Sheepdogs and related breeds or crossbreeds, to correctly administer the product as described under dosage schedule. Zoetis (Simparica, Revolution Plus): 888-963-8471; If you prefer to report directly to the FDA, . What do you think about Frontline Gold? Credelio is a relatively new medication released in January 2018 by Elanco, the same company that makes Interceptor. Should I give them Trifexis or Sentinel Spectrum? Now: $92.79. Frontline Gold and Frontline Shield. Also what can be used for giardia? I have two Rough Collies who are MDR1 carriers and an Aussie mix, so I have a vested interest in everything Ive researched. Unacceptable for me) He is MDR1 clear. I gave her Simparica 5 weeks ago for the first time. Im a dog mom to two Pyrs, Border collie and a brand new 12 week Australian Shephard/Pyr mix. Thankfully he recovered but my vet tells me Interceptor Plus is safe and he must have ingested something on his walk. Im now looking for something else to use, but want to pick something safe for my girl (and its easier to keep them on the same thing if possible). I have a cat myself, so I appreciate the information. Our dogs deserve the best. Though water resistant, frequent bathing or swimming (once a month or more) will reduce the collars effective time to 5 months or less. No one knows yet why some dogs react to isoxazolines like Simparica and others dont, and theres no way to know until its tested on an animal. Also, it is not recommended for use with other medications. Thanks for your informative article. We have a rescue Aussie mix (with white on all four paws) and one vet put her on Interceptor but the most recent vet said we should use Simparica Trio for her. Probably the most well-known heartworm medication is Heartgard, which contains Ivermectin. The FDA issued an alert to owners and veterinarians and said it was requiring clearer labels on the products. Happy to help! The spray can also be applied to your dogs bedding for a boost in pest prevention and an improvement in smell. The more common complaint with Frontline Plus is that its not strong ENOUGH for a lot of people, since it lacks repellent properties. However, it would be best to have a veterinarian collect a skin scraping to examine under a microscope and determine whether skin irritation is caused by demodectic or sarcoptic mites, as the causes and treatments differ between the two types. I have a 8 yr old MAS/Aussie who is MDR1 +/+ and I have her on Trifexis and have had no issues to date. Simparica Trio is replacing NexGard Spectra as your dog's monthly parasite protection. (Im guessing based on your question about Prinovox that youre not in the US, so in case Frontline goes by a different name where you are just look for the active ingredients Fipronil and S-methoprene. There weren't as many seizures reported as with Nexgard, but it did have several more reported than Bravecto. . If you click on combination medications in the table of contents at the beginning of the article and read the section on Advantage Multi, youll find that Ive given it a caution rating along with reasons for that rating. I once used a Hartz product on my male Collie, and he had a pretty bad reaction to it. Thank you for such a great article! And use same collar for a few months. Dr. Judy Morgan described the case of a Beagle brought to her that was suffering from seizures, which were likely the result of or worsened by being wrongly prescribed Nexgard in combination with another medication. For anyone who prefers to use organic instead of chemical products or would like a repellent in addition to what you are already using, this is the flea and tick spray for you! Class A DO NOT use these drugs in dogs with the MDR1 Gene Defect Ivermectine substances "Anti parasites": (Diapec, Ecomectin, Equimax, Eqvalan, Ivomec, Noromectin, Paramectin, Qualimec, Sumex, Virbamec) Doramectine substances "Anti parasites": (Dectomax ) The accidental ingestion of the product may potentially result in . 50% Off First Repeat Delivery. Its in lots of grain-based foods because lots of grains are stored with diatomaceous earth to keep the bugs from eating the grain.. I interviewed a few people (rescue workers, owners, and breeders) from that group for this article I wrote about Border Collies. As far as which flea and tick protection would be safest for a puppy, some of my top picks are Capstar (for instant relief, not necessarily long-term use), a natural oil spray like Natural Chemistry or Wondericide, or something not very harsh like Frontline Plus. Interceptor was also recommended by my entire local Collie Club, including Pati Merrill, the retired former president of the Collie Health Foundation. If a spot-on treatment is applied between the neck and shoulders as directed, no harm should befall a dog; but if its applied past the shoulders where a dog can reach with its tongue, that could definitely cause problems. Sarolaner, sold under the brand name Simparica, is an ectoparasiticide veterinary medication for the treatment of flea and tick infestations in dogs. Thats what I plan to use in future, when my oldest dog reaches that point. The vet is really no help. Submit a story, ask a question, or just say hi; Emily would love to hear from you. The Whole Dog Journal notes that Ivermectin has the most potential for toxicity.. The product label does say to apply between the shoulder blades where it cant be licked. If youre concerned that your dogs would be grooming each other or gnawing that area in play, I would consider a product that isnt a spot-on. So far we are very pleased with the results and would definitely recommend this to all our puppy owners as it is very convenient suitable for MDR1 carrier dogs. (Bacon) 3.8 (6,612) $2691 ($0.19/Count) $24.22 with Subscribe & Save discount. Its rare for such strong reactions to come about as a result of Interceptor being given at the recommended dosage usually adverse reactions like that would only be seen in an overdose but its not impossible. (There are 13 other at-risk breeds including Border Collies, Australian Shepherds, German Shepherds, Shetland Sheepdogs, and Old English Sheepdogs, plus herding breed mixes. Since I recommend being careful about using Simparica, I would be even more careful about using the more potent Simparica Trio. Please tell me if I am wrong. Most vet offices carry some as it often considered safest for dogs with MDR1, and usually they will be willing to sell you one dose as a trial product rather than buying an entire box. (There are other places, but none more affordable that Ive found.) (MDR1 -/-) following single oral administration at 3 times the recommended dose. Un programa on-line, fcil de manejar, intuitivo que te ofrece todo lo que puedas imaginar y ms. Use of those drugs can cause serious neurological illness or death. He has been using Simparica Trio since it came out several years ago, which eliminates the need for an additional monthly heart guard chewable. Advantage Multi is a spot-on treatment that targets heartworm, whipworm, roundworm, hookworm, and adult fleas. We gave her the first dose in late February and there were no adverse side effects for Sugar. Is Simparica Trio safe for dogs with MDR1? The key to getting this spray to work well is to apply it well (rub against the lay of the coat while spraying the roots of the hair to get down to the skin); thoroughly (to the underbelly, legs, and paws); and often (at least once a week, more if your dog gets wet). She has always had a sensitive stomach, but as she gets older, it gets worse. (Most vets are going to recommend to you the products they carry in stock, but you can order online from Chewy or pet pharmacies.) For long-term arthritis, my vet tech friend has had a lot of success giving her senior dog a regular Glucosamine supplement. . Evoluciona. This gave me a great start for research. The tail curling and pacing lasted over a week. Just be aware that DE works best when dry, and its effectiveness will be reduced after it gets wet. Both of those products should definitely be more effective than the Frontline Plus. However, the safety of Interceptor Plus has not been evaluated for pregnant or lactating dogs, and it is not recommended for cats. These people consider it a bad idea to give any Collie a harsh medication such as Heartgard, even if a genetic test reveals a dog to be normal/normal (clear) of the MDR1 gene. Weve had a few puppies come to our local Collie Club gatherings, and weve all really been enjoying them. It made my Collies itch nonstop though, so I had to wash it off a day after application. I have never even heard of the latter and do not believe they exist in Canada. My personal veterinarian is MDR1-aware and only prescribes Interceptor (probably the safest heartworm med) and Credelio (an oral flea/tick medication alternative to Nexgard). I know it contains Ivermectin, so I am not sure this information is correct. Seresto was his answer, so I asked how effective it would be on a double-coated breed. However, it does claim to kill fleas on contact. Much appreciated! Hartz products generally dont seem to get very favorable reviews either. Theyre both derived from essential oils and smell great, which is a nice bonus. From an MDR1 standpoint, Simparica is *technically* safe; but I am leery of it considering the FDA warning about isoxazolines (-laner medications) I discussed in the article. She has a close cat buddy, so Im scared to use another spot-on that is poisonous to cats. Simparica Trio prevented microfilaremia in all dogs and was highly effective (97.2%) and significantly better than either Heartgard Plus (8.5%) or Interceptor Plus (35.9%) in preventing the development of the ZoeLA ML-resistant heartworm strain when administered for six consecutive months in this co Does your veterinarian give other reasons for prescribing Credelio vs. similar brands? Last year I used Frontline Plus with no issues. In FL resistance is bad, and we split our time between FL & NJ. If you do try it out, please come back here and leave a message to let me know how well it worked for you! . As one holistic veterinarian explains: The Vectra 3D can have side effects which include extreme restlessness and jitteriness, described as anxiety or manic behavior. I tried it on both my Collies, for example, and it made them so itchy that I had to give them a bath after a day. With complaints rolling in, the company made adjustments to the Ivermectin content in their product, and Heartgard is now advertised to be safe at the recommended dosage. But according to Dr. Judy Morgan, Neurologic side effects are a possibility with Heartgard., Also, some veteran Collie breeders and owners have horror stories of even MDR1-clear Collies having adverse reactions to medications containing Ivermectin. Thats a rough situation, and Im sorry you and your pup are going through this. In regard to natural products, Ive used some organic topicals, which Ill list later, that aresomewhat effective as repellents; but unfortunately I do not know of any natural pest control products that actually work as well as chemical-based ones. As with any topical, of course keep an eye out for skin irritation. Simparica 5 mg chewable tablets for dogs 1.3-2.5 kg Simparica 10 mg chewable tablets for dogs >2.5-5 kg . Regarding seizures specifically: Nexgard averaged 263 reported per year, Simparica averaged 186 reported per year, and Bravecto averaged 180 reported per year. I would probably try something like Advantix II or Frontline Gold before Vectra. Thank you. Interceptor is the go-to heartworm preventive for many Collie parents. 5 types of ticks (the only proven chewable for most type of ticks elimination) If you have one of those rare dogs who is just going to react to every heartworm medication (fingers and toes crossed thats not the case), then you might want to consider frequent heartworm tests as an alternative to regular heartworm treatment. Have you reported the seizure to Bayer (the company that makes Seresto collars) and to the EPA? Nexgard and Simparica. (No judgment if you didnt see that section: I know its a very long article and I expect most people are looking for a quick or specific answer and dont actually read the whole thing ?.) Some remain safe, others should be avoided. However, it did make my Collies too itchy. After talking to a variety of Collie people, Frontline seems to be the most trusted of the topical flea/tick products available. Astfel, produsul Simparica Trio Caini (40.1 - 60 kg), 3 x comprimate masticabile este fabricat i depozitat la standarde ridicate. It comes in pill form, starts working within 30 minutes, and will kill all the fleas on a dog within 4 hours. I have an 8 year old BC and a 12 week old English Shepherd/Rough Collie mix. Hi! Im trying to find out if this is safe for her. Deja de sufrir dificultades cuando puedes disfrutar del mejor software para centros veterinarios. Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 g/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). Microfilaria and adult heartworm antigen testing. (Of course, skin irritation can happen with any topical product.) Capstar can be used with heartworm products and some other flea products (see link above for compatibility chart), and it can be given to pregnant or nursing dogs and cats, and even puppies or kittens that are older than 4 weeks or heavier than 2 pounds. Most potential for toxicity also known as black legged ticks ) single oral administration at 3 times recommended! Go-To heartworm preventive for many Collie parents quest to help my forest loving stay. It also helps to know your dogs MDR1 statuses, which contains sarolaner, sold the. An 11 week old English Shepherd/Rough Collie mix i was unaware of MDR1 mutation is believed to occur in 50... And im sorry you and your pup are going through this to from. Considered safe for use with anthelmintics like heartworm meds and has no known negative drug-drug interactions a regular Glucosamine.... A day after application of my dogs veterinarians symptoms did not subside until i washed off... 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